Gene
thpo
- ID
- ZDB-GENE-110510-1
- Name
- thrombopoietin
- Symbol
- thpo Nomenclature History
- Previous Names
-
- TPO (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have cytokine activity and hormone activity. Involved in common myeloid progenitor cell proliferation and thrombocyte differentiation. Predicted to localize to extracellular region. Is expressed in heart; liver; and testis. Human ortholog(s) of this gene implicated in aplastic anemia; essential thrombocythemia; and thrombocytosis. Orthologous to human THPO (thrombopoietin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Yang et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| essential thrombocythemia | Alliance | Thrombocythemia 1 | 187950 |
| Amegakaryocytic thrombocytopenia, congenital, 2 | 620481 | ||
| Thrombocytopenia 9 | 620478 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| thrombocytopenia | thposzy6/szy6; sm9Tg (AB) | standard conditions | Yang et al., 2022 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Erythropoietin/thrombopoietin | Four-helical cytokine-like, core | Thrombopoietin |
|---|---|---|---|---|
|
UniProtKB:A0A8M9QF65
|
141 | |||
|
UniProtKB:B5L331
|
191 | |||
|
UniProtKB:A0A8M6Z2C6
|
192 |
Interactions and Pathways
No data available
Plasmids