Gene
fgd4b
- ID
- ZDB-GENE-110421-6
- Name
- FYVE, RhoGEF and PH domain containing 4b
- Symbol
- fgd4b Nomenclature History
- Previous Names
-
- sb:eu921
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cytoskeleton organization and filopodium assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4H. Orthologous to human FGD4 (FYVE, RhoGEF and PH domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu921 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Charcot-Marie-Tooth disease type 4H | Alliance | Charcot-Marie-Tooth disease, type 4H | 609311 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000306 | FYVE zinc finger |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR017455 | Zinc finger, FYVE-related |
| Domain | IPR035941 | FGD1-4, C-terminal PH domain |
| Domain | IPR037742 | FGD4, N-terminal PH domain |
| Domain | IPR055251 | SOS1/NGEF-like, PH domain |
| Family | IPR051092 | FYVE, RhoGEF and PH domain-containing |
| Homologous_superfamily | IPR011011 | Zinc finger, FYVE/PHD-type |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
Domain Details Per Protein
| Protein | Length | Dbl homology (DH) domain superfamily | FGD1-4, C-terminal PH domain | FGD4, N-terminal PH domain | FYVE, RhoGEF and PH domain-containing | FYVE zinc finger | PH-like domain superfamily | Pleckstrin homology domain | SOS1/NGEF-like, PH domain | Zinc finger, FYVE/PHD-type | Zinc finger, FYVE-related | Zinc finger, RING/FYVE/PHD-type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7EYW1
|
653 | |||||||||||
|
UniProtKB:A0A8M1PU37
|
775 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance