Gene
itgb2
- ID
- ZDB-GENE-110411-4
- Name
- integrin, beta 2
- Symbol
- itgb2 Nomenclature History
- Previous Names
-
- si:dkey-260n18.4
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable amyloid-beta binding activity and integrin binding activity. Acts upstream of with a negative effect on definitive hemopoiesis. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in cell surface and focal adhesion. Is expressed in caudal hematopoietic tissue. Human ortholog(s) of this gene implicated in coronary restenosis; leukocyte adhesion deficiency; and leukocyte adhesion deficiency 1. Orthologous to human ITGB2 (integrin subunit beta 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Xue et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Xue et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| leukocyte adhesion deficiency 1 | Alliance | Leukocyte adhesion deficiency | 116920 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR002369 | Integrin beta subunit, VWA domain |
| Domain | IPR012896 | Integrin beta subunit, tail |
| Domain | IPR013111 | EGF-like domain, extracellular |
| Domain | IPR014836 | Integrin beta subunit, cytoplasmic domain |
| Domain | IPR016201 | PSI domain |
| Domain | IPR033760 | Integrin beta N-terminal |
| Family | IPR015812 | Integrin beta subunit |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Homologous_superfamily | IPR036349 | Integrin beta tail domain superfamily |
| Homologous_superfamily | IPR036465 | von Willebrand factor A-like domain superfamily |
Domain Details Per Protein
| Protein | Length | EGF-like domain, extracellular | Integrin beta N-terminal | Integrin beta subunit | Integrin beta subunit, cytoplasmic domain | Integrin beta subunit, tail | Integrin beta subunit, VWA domain | Integrin beta tail domain superfamily | Integrin domain superfamily | PSI domain | von Willebrand factor A-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FCN5
|
768 |
Interactions and Pathways
No data available
Plasmids
No data available