Gene

bcl2b

ID

ZDB-GENE-110411-185

Name

BCL2 apoptosis regulator b

Symbol

bcl2b Nomenclature History

Previous Names

si:dkey-217f4.3 (1)

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have protein heterodimerization activity and protein homodimerization activity. Predicted to be involved in extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of intrinsic apoptotic signaling pathway. Predicted to localize to mitochondrial outer membrane. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; carcinoma (multiple); hematologic cancer (multiple); intracranial aneurysm; and prostate cancer. Orthologous to human BCL2 (BCL2 apoptosis regulator).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With bcl2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Leukemia/lymphoma, B-cell, 2

Associated With bcl2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
Conserved_site	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
Domain	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4
Domain	IPR046371	Bcl-2, Bcl-2 homology region 1-3
Family	IPR002475	Bcl2-like
Family	IPR013279	Apoptosis regulator, Bcl-X
Family	IPR026298	Bcl-2 family
Homologous_superfamily	IPR036834	Bcl-2-like superfamily

Domain Details Per Protein

Protein	Length	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Apoptosis regulator, Bcl-2, BH2 motif, conserved site	Apoptosis regulator, Bcl-2 protein, BH4	Apoptosis regulator, Bcl-X	Bcl-2, Bcl-2 homology region 1-3	Bcl-2 family	Bcl2-like	Bcl-2-like superfamily
UniProtKB:F8W266 InterPro	209

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	bcl2b-201 (1) Ensembl	Ensembl		4,017 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations