Gene
capn10
- ID
- ZDB-GENE-110411-137
- Name
- calpain 10
- Symbol
- capn10 Nomenclature History
- Previous Names
-
- si:ch73-216b13.1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within cellular response to insulin stimulus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in obesity; pancreatic cancer; polycystic ovary syndrome; and type 2 diabetes mellitus. Orthologous to human CAPN10 (calpain 10).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| type 2 diabetes mellitus | Alliance | {Diabetes mellitus, noninsulin-dependent 1} | 601283 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Domain | IPR001300 | Peptidase C2, calpain, catalytic domain |
| Domain | IPR022682 | Peptidase C2, calpain, large subunit, domain III |
| Domain | IPR022683 | Peptidase C2, calpain, domain III |
| Family | IPR022684 | Peptidase C2, calpain family |
| Homologous_superfamily | IPR036213 | Calpain large subunit, domain III superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | Calpain large subunit, domain III superfamily | Cysteine peptidase, cysteine active site | Papain-like cysteine peptidase superfamily | Peptidase C2, calpain, catalytic domain | Peptidase C2, calpain, domain III | Peptidase C2, calpain family | Peptidase C2, calpain, large subunit, domain III |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7UW33
|
649 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
capn10-201
(1)
|
Ensembl | 1,977 nt | ||
| mRNA |
capn10-202
(1)
|
Ensembl | 2,684 nt | ||
| mRNA |
capn10-203
(1)
|
Ensembl | 421 nt |
Interactions and Pathways
No data available
Plasmids
No data available