Gene
kcna1a
- ID
- ZDB-GENE-110408-15
- Name
- potassium voltage-gated channel, shaker-related subfamily, member 1a
- Symbol
- kcna1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport; potassium ion transport; and protein homooligomerization. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in several cellular components, including dendrite; main axon; and neuronal cell body. Is expressed in several structures, including gill; heart; hindbrain; opercular flap; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| episodic ataxia type 1 | Alliance | Episodic ataxia/myokymia syndrome | 160120 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000210 | BTB/POZ domain |
| Domain | IPR003131 | Potassium channel tetramerisation-type BTB domain |
| Domain | IPR005821 | Ion transport domain |
| Family | IPR003968 | Potassium channel, voltage dependent, Kv |
| Family | IPR003972 | Potassium channel, voltage dependent, Kv1 |
| Family | IPR004048 | Potassium channel, voltage dependent, Kv1.1 |
| Family | IPR028325 | Voltage-gated potassium channel |
| Homologous_superfamily | IPR011333 | SKP1/BTB/POZ domain superfamily |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Length | BTB/POZ domain | Ion transport domain | Potassium channel tetramerisation-type BTB domain | Potassium channel, voltage dependent, Kv | Potassium channel, voltage dependent, Kv1 | Potassium channel, voltage dependent, Kv1.1 | SKP1/BTB/POZ domain superfamily | Voltage-dependent channel domain superfamily | Voltage-gated potassium channel |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FFE9
|
492 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcna1a-201
(1)
|
Ensembl | 1,479 nt | ||
| mRNA |
kcna1a-202
(1)
|
Ensembl | 3,380 nt |
Interactions and Pathways
No data available
Plasmids