Gene

lig1

ID

ZDB-GENE-110404-2

Name

ligase I, DNA, ATP-dependent

Symbol

lig1 Nomenclature History

Previous Names

si:dkeyp-35b8.5
si:dkeyp-35b8.7
wu:fc54a11

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Predicted to be involved in Okazaki fragment processing involved in mitotic DNA replication. Predicted to act upstream of or within DNA metabolic process. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in inherited metabolic disorder and primary immunodeficiency disease. Orthologous to human LIG1 (DNA ligase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Leontovich et al., 2016

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lig1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Immunodeficiency 96	619774

Associated With lig1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR016059	DNA ligase, ATP-dependent, conserved site
Domain	IPR012308	DNA ligase, ATP-dependent, N-terminal
Domain	IPR012309	DNA ligase, ATP-dependent, C-terminal
Domain	IPR012310	DNA ligase, ATP-dependent, central
Family	IPR000977	DNA ligase, ATP-dependent
Family	IPR050191	ATP-dependent DNA ligase
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold
Homologous_superfamily	IPR036599	DNA ligase, ATP-dependent, N-terminal domain superfamily