Gene
akt3b
- ID
- ZDB-GENE-110309-3
- Name
- v-akt murine thymoma viral oncogene homolog 3b
- Symbol
- akt3b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Thyme et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 | 615937 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| schizophrenia | akt3ba230/a230 | standard conditions | Thyme et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000961 | AGC-kinase, C-terminal |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR017892 | Protein kinase, C-terminal |
| Domain | IPR039026 | Protein Kinase B, pleckstrin homology domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
Domain Details Per Protein
| Protein | Length | AGC-kinase, C-terminal | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein Kinase B, pleckstrin homology domain | Protein kinase, C-terminal | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7EXT6
|
479 |
Interactions and Pathways
No data available
Plasmids
No data available