Gene

abcc6b.2

ID

ZDB-GENE-110208-2

Name

ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2

Symbol

abcc6b.2 Nomenclature History

Previous Names

abcc6c
zmp:0000001324

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; ATPase activity; and ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in arterial calcification of infancy; coronary artery disease; and pseudoxanthoma elasticum. Orthologous to human ABCC6 (ATP binding cassette subfamily C member 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Li et al., 2010

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Li et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abcc6b.2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
arterial calcification of infancy	Alliance	Arterial calcification, generalized, of infancy, 2	614473
pseudoxanthoma elasticum	Alliance	Pseudoxanthoma elasticum	264800
pseudoxanthoma elasticum	Alliance	Pseudoxanthoma elasticum, forme fruste	177850

Associated With abcc6b.2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR011527	ABC transporter type 1, transmembrane domain
Family	IPR005292	Multi drug resistance-associated protein
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036640	ABC transporter type 1, transmembrane domain superfamily

Domain Details Per Protein

Protein	Length	AAA+ ATPase domain	ABC transporter-like, ATP-binding domain	ABC transporter-like, conserved site	ABC transporter type 1, transmembrane domain	ABC transporter type 1, transmembrane domain superfamily	Multi drug resistance-associated protein	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A140LGU2 InterPro	1502
UniProtKB:A0A8M6YXP8 InterPro	1502
UniProtKB:A0A8M9PZJ9 InterPro	829

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	abcc6b.2-201 (1) Ensembl	Ensembl	4,368 nt	Select Tool ZFIN BLAST
mRNA	abcc6b.2-202 (1) Ensembl	Ensembl	4,934 nt	Select Tool ZFIN BLAST
mRNA	abcc6b.2-203 (1) Ensembl	Ensembl	4,326 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations