Gene
kcnma1b
- ID
- ZDB-GENE-101209-2
- Name
- potassium large conductance calcium-activated channel, subfamily M, alpha member 1b
- Symbol
- kcnma1b Nomenclature History
- Previous Names
-
- slo1b (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have large conductance calcium-activated potassium channel activity. Involved in response to auditory stimulus. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| paroxysmal nonkinesigenic dyskinesia 3 | Alliance | Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy | 609446 |
| Cerebellar atrophy, developmental delay, and seizures | 617643 | ||
| Liang-Wang syndrome | 618729 | ||
| {Epilepsy, idiopathic generalized, susceptibility to, 16} | 618596 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003929 | Calcium-activated potassium channel BK, alpha subunit |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR048735 | Ca2+-activated K+ channel Slowpoke-like, C-terminal domain |
| Family | IPR047871 | Calcium-activated potassium channel slowpoke-like |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Ca2+-activated K+ channel Slowpoke-like, C-terminal domain | Calcium-activated potassium channel BK, alpha subunit | Calcium-activated potassium channel slowpoke-like | Ion transport domain | NAD(P)-binding domain superfamily |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PXE8
|
1107 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnma1-201
(1)
|
Ensembl | 1,389 nt |
Interactions and Pathways
No data available
Plasmids
- Comparative Orthology
- Alliance