Gene

mtrr

ID

ZDB-GENE-101115-3

Name

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

Symbol

mtrr Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have coenzyme binding activity and oxidoreductase activity. Predicted to be involved in homocysteine metabolic process and methionine biosynthetic process. Predicted to localize to cytosol. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and ulcerative colitis. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Burkhalter et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Burkhalter et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mtrr Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
homocystinuria-megaloblastic anemia cblE type	Alliance	Homocystinuria-megaloblastic anemia, cbl E type	236270
neural tube defect	Alliance	{Neural tube defects, folate-sensitive, susceptibility to}	601634

Associated With mtrr Via Experimental Models

Human Disease	Fish	Conditions	Citations
visceral heterotaxy	WT + MO1-mtrr	standard conditions	Burkhalter et al., 2019

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001094	Flavodoxin-like
Domain	IPR001433	Oxidoreductase FAD/NAD(P)-binding
Domain	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
Domain	IPR003097	Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain	IPR008254	Flavodoxin/nitric oxide synthase
Domain	IPR017927	FAD-binding domain, ferredoxin reductase-type
Homologous_superfamily	IPR017938	Riboflavin synthase-like beta-barrel
Homologous_superfamily	IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous_superfamily	IPR029039	Flavoprotein-like superfamily
Homologous_superfamily	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

Domain Details Per Protein

Protein	Length	FAD-binding domain, ferredoxin reductase-type	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Flavodoxin-like	Flavodoxin/nitric oxide synthase	Flavoprotein-like superfamily	Flavoprotein pyridine nucleotide cytochrome reductase	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily	Oxidoreductase FAD/NAD(P)-binding	Riboflavin synthase-like beta-barrel	Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
UniProtKB:A0A0R4IZR6 InterPro	695
UniProtKB:F1RE28 InterPro	697
UniProtKB:A0A8M2B9H1 InterPro	696

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mtrr-201 (1) Ensembl	Ensembl	2,637 nt	Select Tool
mRNA	mtrr-202 (1) Ensembl	Ensembl	633 nt	Select Tool
mRNA	mtrr-203 (1) Ensembl	Ensembl	1,742 nt	Select Tool
mRNA	mtrr-205 (1) Ensembl	Ensembl	571 nt	Select Tool
mRNA	mtrr-206 (1) Ensembl	Ensembl	6,881 nt	Select Tool ZFIN BLAST
mRNA	mtrr-207 (1) Ensembl	Ensembl	7,564 nt	Select Tool ZFIN BLAST
ncRNA	mtrr-004 (1) Ensembl	Ensembl	538 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations