Gene
myh14
- ID
- ZDB-GENE-100921-1
- Name
- myosin, heavy chain 14, non-muscle
- Symbol
- myh14 Nomenclature History
- Previous Names
-
- si:ch211-120k19.2
- si:ch211-120k19.3
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be part of myosin II complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Huang et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 4A | Alliance | Deafness, autosomal dominant 4A | 600652 |
| ?Peripheral neuropathy, myopathy, hoarseness, and hearing loss | 614369 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain-like |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain-like | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AQG4
|
2065 | |||||||
|
UniProtKB:A0A8M3AJ07
|
2049 | |||||||
|
UniProtKB:A0A8M3B1K3
|
2056 | |||||||
|
UniProtKB:A0A8M3AHY4
|
2061 | |||||||
|
UniProtKB:A0A8M2B482
|
2060 | |||||||
|
UniProtKB:A0A8M2B4A6
|
2036 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance