Gene

myh14

ID

ZDB-GENE-100921-1

Name

myosin, heavy chain 14, non-muscle

Symbol

myh14 Nomenclature History

Previous Names

si:ch211-120k19.2
si:ch211-120k19.3

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (myosin heavy chain 14).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Huang et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With myh14 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 4A	Alliance	Deafness, autosomal dominant 4A	600652
		?Peripheral neuropathy, myopathy, hoarseness, and hearing loss	614369

Associated With myh14 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR000048	IQ motif, EF-hand binding site
Domain	IPR002928	Myosin tail
Domain	IPR004009	Myosin, N-terminal, SH3-like
Homologous_superfamily	IPR008989	Myosin S1 fragment, N-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036961	Kinesin motor domain superfamily

Domain Details Per Protein

Protein	Length	IQ motif, EF-hand binding site	Kinesin motor domain superfamily	Myosin, N-terminal, SH3-like	Myosin S1 fragment, N-terminal	Myosin tail	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A8M3AQG4 InterPro	2065
UniProtKB:A0A8M3AJ07 InterPro	2049
UniProtKB:A0A8M3B1K3 InterPro	2056
UniProtKB:A0A8M3AHY4 InterPro	2061
UniProtKB:A0A8M2B482 InterPro	2060
UniProtKB:A0A8M2B4A6 InterPro	2036

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	myh14-201 (1) Ensembl	Ensembl	6,260 nt	Select Tool ZFIN BLAST
mRNA	myh14-203 (1) Ensembl	Ensembl	12,826 nt	Select Tool
mRNA	myh14-204 (1) Ensembl	Ensembl	446 nt	Select Tool
ncRNA	myh14-002 (1) Ensembl	Ensembl	529 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations