Gene
npr1b
- ID
- ZDB-GENE-100805-4
- Name
- natriuretic peptide receptor 1b
- Symbol
- npr1b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Involved in olfactory bulb axon guidance. Predicted to localize to plasma membrane. Is expressed in several structures, including eye; fin; integument; muscle; and renal system. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human NPR1 (natriuretic peptide receptor 1).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Gong et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Conserved_site | IPR018297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001054 | Adenylyl cyclase class-3/4/guanylyl cyclase |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR001828 | Receptor, ligand binding region |
Family | IPR001170 | Adenylyl cyclase class-4/guanylyl cyclase |
Family | IPR050401 | Cyclic nucleotide synthase |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR028082 | Periplasmic binding protein-like I |
Homologous_superfamily | IPR029787 | Nucleotide cyclase |
Domain Details Per Protein
Protein | Length | Adenylyl cyclase class-3/4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Cyclic nucleotide synthase | Nucleotide cyclase | Periplasmic binding protein-like I | Protein kinase domain | Protein kinase-like domain superfamily | Receptor, ligand binding region | Serine-threonine/tyrosine-protein kinase, catalytic domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:F8W5M5
|
817 | ||||||||||
UniProtKB:E7F3T9
|
1070 | ||||||||||
UniProtKB:A0A8M3AQN2
|
1070 |
Interactions and Pathways
No data available
Plasmids
No data available