Gene

thbs2b

ID

ZDB-GENE-100623-1

Name

thrombospondin 2b

Symbol

thbs2b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity and heparin binding activity. Predicted to be involved in negative regulation of angiogenesis. Predicted to act upstream of or within cell adhesion. Predicted to be located in extracellular region. Orthologous to human THBS2 (thrombospondin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With thbs2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Ehlers-Danlos syndrome, classic-like, 3	620865
		{Lumbar disc herniation, susceptibility to}	603932

Associated With thbs2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR001007	VWFC domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR008859	Thrombospondin, C-terminal
Domain	IPR024731	EGF domain
Domain	IPR048287	Thrombospondin-like, N-terminal domain
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR028974	TSP type-3 repeat
Homologous_superfamily	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily
Repeat	IPR000884	Thrombospondin type-1 (TSP1) repeat
Repeat	IPR003367	Thrombospondin, type 3-like repeat
Repeat	IPR017897	Thrombospondin, type 3 repeat

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF domain	EGF-like calcium-binding domain	EGF-like domain	Thrombospondin, C-terminal	Thrombospondin-like, N-terminal domain	Thrombospondin type-1 (TSP1) repeat	Thrombospondin type-1 (TSP1) repeat superfamily	Thrombospondin, type 3-like repeat	Thrombospondin, type 3 repeat	TSP type-3 repeat	VWFC domain
UniProtKB:A0A8M3B7K3 InterPro	1181

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	thbs2b-201 (1) Ensembl	Ensembl	4,419 nt	Select Tool ZFIN BLAST
mRNA	thbs2b-203 (1) Ensembl	Ensembl	3,519 nt	Select Tool ZFIN BLAST
ncRNA	thbs2b-002 (1) Ensembl	Ensembl	859 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations