Gene
timp4.1
- ID
- ZDB-GENE-100603-1
- Name
- TIMP metallopeptidase inhibitor 4, tandem duplicate 1
- Symbol
- timp4.1 Nomenclature History
- Previous Names
-
- timp4
- timp4b
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of proteolysis; response to cytokine; and response to hormone. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in prechordal plate. Human ortholog(s) of this gene implicated in nephroblastoma. Orthologous to human TIMP4 (TIMP metallopeptidase inhibitor 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Farrell et al., 2018
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Netrin domain | Protease inhibitor I35 (TIMP) | Proteinase inhibitor I35b (TIMP), C-terminal | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|
|
UniProtKB:E7FEZ5
|
|||||
|
UniProtKB:A0A2R8Q0U9
|
229 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
timp4.1-201
(1)
|
Ensembl | 1,528 nt |
Interactions and Pathways
No data available
Plasmids
No data available