Gene

inpp5kb

ID

ZDB-GENE-100408-3

Name

inositol polyphosphate-5-phosphatase Kb

Symbol

inpp5kb Nomenclature History

Previous Names

inpp5k

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Description

Predicted to have inositol bisphosphate phosphatase activity; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in camera-type eye development and skeletal muscle fiber development. Predicted to localize to endoplasmic reticulum; plasma membrane; and ruffle. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to human INPP5K (inositol polyphosphate-5-phosphatase K).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With inpp5kb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital muscular dystrophy with cataracts and intellectual disability	Alliance	Muscular dystrophy, congenital, with cataracts and intellectual disability	617404

Associated With inpp5kb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000300	Inositol polyphosphate-related phosphatase
Domain	IPR041611	SKICH domain
Family	IPR046985	Inositol 5-phosphatase
Homologous_superfamily	IPR036691	Endonuclease/exonuclease/phosphatase superfamily

Domain Details Per Protein

Protein	Length	Endonuclease/exonuclease/phosphatase superfamily	Inositol 5-phosphatase	Inositol polyphosphate-related phosphatase	SKICH domain
UniProtKB:A0A8M2B261 InterPro	526
UniProtKB:A0A8M2B205 InterPro	517
UniProtKB:A0A8N7UTA0 InterPro	468
UniProtKB:A0A8M9QL16 InterPro	517
UniProtKB:A0A2R8QKI3 InterPro	526
UniProtKB:A0A8M9QH03 InterPro	459

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
antisense	ottdart00000059909 (1) Ensembl	Ensembl	953 nt	Select Tool ZFIN BLAST
mRNA	inpp5kb-201 (1) Ensembl	Ensembl	3,508 nt	Select Tool ZFIN BLAST
mRNA	inpp5kb-202 (1) Ensembl	Ensembl	1,467 nt	Select Tool ZFIN BLAST
mRNA	inpp5kb-203 (1) Ensembl	Ensembl	3,682 nt	Select Tool ZFIN BLAST
mRNA	inpp5kb-204 (1) Ensembl	Ensembl	3,535 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations