Gene
tnfaip3
- ID
- ZDB-GENE-100212-2
- Name
- tumor necrosis factor, alpha-induced protein 3
- Symbol
- tnfaip3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and cysteine-type deubiquitinase activity. Acts upstream of or within cranial skeletal system development and negative regulation of NIK/NF-kappaB signaling. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; esophageal cancer; and familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| familial Behcet-like autoinflammatory syndrome | Alliance | Autoinflammatory syndrome, familial, Behcet-like 1 | 616744 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | OTU domain | OTU Domain-Containing Deubiquitinase | Zinc finger, A20-type |
|---|---|---|---|---|
|
UniProtKB:A0A8N7T672
|
762 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
tnfaip3-201
(1)
|
Ensembl | 2,253 nt | ||
| mRNA |
tnfaip3-202
(1)
|
Ensembl | 2,271 nt | ||
| mRNA |
tnfaip3-203
(1)
|
Ensembl | 2,193 nt |
Interactions and Pathways
No data available
Plasmids
No data available