Gene

dennd3a

ID

ZDB-GENE-091230-6

Name

DENN/MADD domain containing 3a

Symbol

dennd3a Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within enteric nervous system development. Predicted to be active in cytoplasmic vesicle. Is expressed in central nervous system and intestine. Orthologous to human DENND3 (DENN domain containing 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Gui et al., 2017

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dennd3a Human Ortholog

No data available

Associated With dennd3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001194	cDENN domain
Domain	IPR005112	dDENN domain
Domain	IPR005113	uDENN domain
Domain	IPR037516	Tripartite DENN domain
Family	IPR051696	DENN Domain-Containing GEFs
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR043153	DENN domain, C-terminal lobe

Domain Details Per Protein

Protein	Length	cDENN domain	dDENN domain	DENN Domain-Containing GEFs	DENN domain, C-terminal lobe	Tripartite DENN domain	uDENN domain	WD40-repeat-containing domain superfamily	WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:A0A8M1Q1P5 InterPro	1270
UniProtKB:A0A8M9P256 InterPro	1285

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	dennd3a-201 (1) Ensembl	Ensembl		6,986 nt	Select Tool ZFIN BLAST
mRNA	dennd3a-202 (1) Ensembl	Ensembl		1,942 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations