Gene
nnt2
- ID
- ZDB-GENE-091204-5
- Name
- nicotinamide nucleotide transhydrogenase 2
- Symbol
- nnt2 Nomenclature History
- Previous Names
-
- si:ch1073-139a18.1
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have NAD binding activity; NAD(P)+ transhydrogenase activity; and NADP binding activity. Predicted to be involved in NADPH regeneration. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human NNT (nicotinamide nucleotide transhydrogenase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Glucocorticoid deficiency 4, with or without mineralocorticoid deficiency | 614736 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR008143 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 |
| Domain | IPR007698 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain |
| Domain | IPR007886 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal |
| Domain | IPR024605 | NAD(P) transhydrogenase, alpha subunit, C-terminal |
| Domain | IPR034300 | NADP transhydrogenase beta-like domain |
| Family | IPR026255 | NAD(P) transhydrogenase, alpha subunit |
| Homologous_superfamily | IPR029035 | DHS-like NAD/FAD-binding domain superfamily |
| Homologous_superfamily | IPR036291 | NAD(P)-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2 | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain | Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal | DHS-like NAD/FAD-binding domain superfamily | NAD(P)-binding domain superfamily | NAD(P) transhydrogenase, alpha subunit | NAD(P) transhydrogenase, alpha subunit, C-terminal | NADP transhydrogenase beta-like domain |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z2N7
|
1069 |
Interactions and Pathways
No data available
Plasmids
No data available