Gene

sh3kbp1

ID

ZDB-GENE-091204-186

Name

SH3-domain kinase binding protein 1

Symbol

sh3kbp1 Nomenclature History

Previous Names

cin85 (1)
si:dkey-108d10.1 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Involved in blood vessel lumenization. Is expressed in axial blood vessel; caudal vein plexus; intermediate mesoderm; and notochord. Orthologous to human SH3KBP1 (SH3 domain containing kinase binding protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Zhao et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Zhao et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sh3kbp1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
immunodeficiency 61	Alliance	?Immunodeficiency 61	300310

Associated With sh3kbp1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR035770	SH3 domain-containing kinase-binding protein 1, first SH3 domain
Domain	IPR035772	SH3 domain-containing kinase-binding protein 1, third SH3 domain
Family	IPR050384	Endophilin/SH3RF
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Endophilin/SH3RF	SH3 domain	SH3 domain-containing kinase-binding protein 1, first SH3 domain	SH3 domain-containing kinase-binding protein 1, third SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M9P657 InterPro	632
UniProtKB:A0A8M9PGF3 InterPro	622
UniProtKB:A0A8M2B9Q8 InterPro	393
UniProtKB:A0A8M9PX84 InterPro	580
UniProtKB:A0A8M1RMS5 InterPro	634

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	sh3kbp1-201 (1) Ensembl	Ensembl		2,007 nt	Select Tool ZFIN BLAST
mRNA	sh3kbp1-202 (1) Ensembl	Ensembl		2,651 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations