Gene
capn5b
- ID
- ZDB-GENE-091116-29
- Name
- calpain 5b
- Symbol
- capn5b Nomenclature History
- Previous Names
-
- si:dkey-163i6.4
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in neovascular inflammatory vitreoretinopathy. Is expressed in nervous system. Orthologous to human CAPN5 (calpain 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neovascular inflammatory vitreoretinopathy | Alliance | Vitreoretinopathy, neovascular inflammatory | 193235 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Domain | IPR000008 | C2 domain |
| Domain | IPR001300 | Peptidase C2, calpain, catalytic domain |
| Domain | IPR022682 | Peptidase C2, calpain, large subunit, domain III |
| Domain | IPR022683 | Peptidase C2, calpain, domain III |
| Domain | IPR033883 | Calpain subdomain III |
| Domain | IPR033884 | Calpain C2 domain |
| Family | IPR022684 | Peptidase C2, calpain family |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036213 | Calpain large subunit, domain III superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | Calpain C2 domain | Calpain large subunit, domain III superfamily | Calpain subdomain III | Cysteine peptidase, cysteine active site | Papain-like cysteine peptidase superfamily | Peptidase C2, calpain, catalytic domain | Peptidase C2, calpain, domain III | Peptidase C2, calpain family | Peptidase C2, calpain, large subunit, domain III |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q9W0
|
642 | |||||||||||
|
UniProtKB:E7F7F1
|
642 | |||||||||||
|
UniProtKB:A0A8M3ATX3
|
659 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
capn5b-201
(1)
|
Ensembl | 1,943 nt |
Interactions and Pathways
No data available
Plasmids
No data available