Gene

dyrk4

ID

ZDB-GENE-091015-3

Name

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

Symbol

dyrk4 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Predicted to localize to cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK4 (dual specificity tyrosine phosphorylation regulated kinase 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dyrk4 Human Ortholog

No data available

Associated With dyrk4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050494	Serine/threonine and dual-specificity kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR042521	Dual specificity tyrosine-phosphorylation-regulated kinase

Domain Details Per Protein

Protein	Length	Dual specificity tyrosine-phosphorylation-regulated kinase	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine and dual-specificity kinase	Serine/threonine-protein kinase, active site
UniProtKB:A0A2R8RWZ6 InterPro	606
UniProtKB:A0A8M9PYX5 InterPro	627
UniProtKB:A0A2R8Q5G9 InterPro	644
UniProtKB:E7F1S5 InterPro	634
UniProtKB:A0A2R8Q5R9 InterPro	616

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	dyrk4-201 (1) Ensembl	Ensembl	2,998 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-202 (1) Ensembl	Ensembl	647 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-203 (1) Ensembl	Ensembl	4,593 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-204 (1) Ensembl	Ensembl	4,530 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-205 (1) Ensembl	Ensembl	5,617 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-206 (1) Ensembl	Ensembl	5,220 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-207 (1) Ensembl	Ensembl	4,509 nt	Select Tool ZFIN BLAST
mRNA	dyrk4-208 (1) Ensembl	Ensembl	5,533 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations