Gene
lrp6
- ID
- ZDB-GENE-090821-1
- Name
- low density lipoprotein receptor-related protein 6
- Symbol
- lrp6 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Ambiguous Mapping Details/Browsers
- Description
- Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in canonical Wnt signaling pathway and dorsal/ventral axis specification. Predicted to localize to plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in tooth agenesis. Is expressed in posterior lateral line primordium. Orthologous to human LRP6 (LDL receptor related protein 6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| coronary artery disease | Alliance | {Coronary artery disease, autosomal dominant, 2} | 610947 |
| Tooth agenesis, selective, 7 | 616724 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Family | IPR017049 | Low density lipoprotein receptor-related protein 5/6 |
| Family | IPR050778 | Cueball/EGF/LRP/Nidogen |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | Cueball/EGF/LRP/Nidogen | EGF-like domain | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Low density lipoprotein receptor-related protein 5/6 | Six-bladed beta-propeller, TolB-like |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:B5L5I6
|
1620 |
- Genome Browsers
Interactions and Pathways
Plasmids
No data available