Gene
cacna1g
- ID
- ZDB-GENE-090514-2
- Name
- calcium channel, voltage-dependent, T type, alpha 1G subunit
- Symbol
- cacna1g Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Predicted to be involved in several processes, including metal ion transport; neuronal action potential; and positive regulation of calcium ion-dependent exocytosis. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of monoatomic ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42. Orthologous to human CACNA1G (calcium voltage-gated channel subunit alpha1 G).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia type 42 | Alliance | Spinocerebellar ataxia 42 | 616795 |
| Spinocerebellar ataxia 42, early-onset, severe, with neurodevelopmental deficits | 618087 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
| Family | IPR005445 | Voltage-dependent calcium channel, T-type, alpha-1 subunit |
| Family | IPR043203 | Voltage-gated cation channel calcium and sodium |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Length | Ion transport domain | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, T-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-gated cation channel calcium and sodium |
|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QER5
|
2414 | |||||
|
UniProtKB:A0A8M9QJ76
|
2462 | |||||
|
UniProtKB:A0A8M6Z8Y9
|
2456 | |||||
|
UniProtKB:A0A8M6Z3L0
|
2469 | |||||
|
UniProtKB:A0A8M6Z219
|
2447 | |||||
|
UniProtKB:A0A8M9PX46
|
2462 | |||||
|
UniProtKB:A0A8M9QER1
|
2503 | |||||
|
UniProtKB:A0A8M9Q929
|
2440 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1g-201
(1)
|
Ensembl | 6,720 nt | ||
| mRNA |
cacna1g-202
(1)
|
Ensembl | 5,635 nt |
Interactions and Pathways
No data available
Plasmids
No data available