Gene

tuba1a

ID

ZDB-GENE-090507-4

Name

tubulin, alpha 1a

Symbol

tuba1a Nomenclature History

Previous Names

tuba1l2
wu:fb37a10

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have GTP binding activity. Involved in negative regulation of apoptotic process and optic nerve formation. Predicted to localize to cytoplasm and microtubule. Human ortholog(s) of this gene implicated in lissencephaly; microcephaly; and visual epilepsy. Orthologous to human TUBA1A (tubulin alpha 1a).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:85639 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Veldman et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tuba1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lissencephaly 3	Alliance	Lissencephaly 3	611603

Associated With tuba1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017975	Tubulin, conserved site
Domain	IPR003008	Tubulin/FtsZ, GTPase domain
Domain	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
Family	IPR000217	Tubulin
Family	IPR002452	Alpha tubulin
Homologous_superfamily	IPR008280	Tubulin/FtsZ, C-terminal
Homologous_superfamily	IPR023123	Tubulin, C-terminal
Homologous_superfamily	IPR036525	Tubulin/FtsZ, GTPase domain superfamily
Homologous_superfamily	IPR037103	Tubulin/FtsZ-like, C-terminal domain