Gene

tlr4al

ID

ZDB-GENE-090507-2

Name

toll-like receptor 4a, like

Symbol

tlr4al Nomenclature History

Previous Names

tlr4ba (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable lipopolysaccharide binding activity and lipopolysaccharide immune receptor activity. Predicted to be involved in defense response to Gram-negative bacterium; inflammatory response; and toll-like receptor signaling pathway. Predicted to act upstream of or within innate immune response and signal transduction. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human TLR4 (toll like receptor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Oyarbide et al., 2015

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr4al Human Ortholog

No data available

Associated With tlr4al Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Family	IPR017241	Toll-like receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype