Gene

arhgef38

ID

ZDB-GENE-090313-83

Name

Rho guanine nucleotide exchange factor (GEF) 38

Symbol

arhgef38 Nomenclature History

Previous Names

si:ch211-216c6.3

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in Golgi stack and cell junction. Orthologous to human ARHGEF38 (Rho guanine nucleotide exchange factor 38).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Lansdon et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arhgef38 Human Ortholog

No data available

Associated With arhgef38 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001452	SH3 domain
Domain	IPR004148	BAR domain
Family	IPR051492	Dynamin-binding and Rho GEF
Homologous_superfamily	IPR027267	AH/BAR domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	AH/BAR domain superfamily	BAR domain	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	Dynamin-binding and Rho GEF	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M3ASM7 InterPro	762
UniProtKB:A0A8M3AIF8 InterPro	548

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	arhgef38-201 (1) Ensembl	Ensembl		2,764 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations