Gene

dkk1a

ID

ZDB-GENE-090313-406

Name

dickkopf WNT signaling pathway inhibitor 1a

Symbol

dkk1a Nomenclature History

Previous Names

si:dkeyp-86d6.1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable co-receptor binding activity and receptor antagonist activity. Acts upstream of or within neuromast development and sensory epithelium regeneration. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including eye; heart; male organism; otic vesicle; and solid lens vesicle. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

11 figures from 10 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With dkk1a Human Ortholog

No data available

Associated With dkk1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006796	Dickkopf, N-terminal cysteine-rich
Domain	IPR047304	Dickkopf-related protein 1, second cysteine-rich domain
Domain	IPR048499	Dickkopf-related protein 1/2/4, C-terminal subdomain 2
Domain	IPR048500	Dickkopf-related protein 1/2/4, C-terminal subdomain 1
Family	IPR039863	Dickkopf related protein 1-4