Gene

wdr19

ID

ZDB-GENE-090313-277

Name

WD repeat domain 19

Symbol

wdr19 Nomenclature History

Previous Names

si:dkey-251e24.6

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Acts upstream of or within cilium assembly. Predicted to be part of intraciliary transport particle A. Predicted to be active in cilium. Human ortholog(s) of this gene implicated in several diseases, including Caroli disease; Senior-Loken syndrome; asphyxiating thoracic dystrophy 5; cranioectodermal dysplasia 4; and nephronophthisis 13. Orthologous to human WDR19 (WD repeat domain 19).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ryan et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wdr19 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
asphyxiating thoracic dystrophy 5	Alliance	Short-rib thoracic dysplasia 5 with or without polydactyly	614376
cranioectodermal dysplasia 4	Alliance	Cranioectodermal dysplasia 4	614378
nephronophthisis 13	Alliance	Nephronophthisis 13	614377
spermatogenic failure 72	Alliance	?Spermatogenic failure 72	619867
		Senior-Loken syndrome 8	616307

Associated With wdr19 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain
Family	IPR040379	WD repeat-containing protein 19/dyf-2
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Repeat	IPR001680	WD40 repeat

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PX63	InterPro	1345
UniProtKB:A0A8M9Q0I2	InterPro	1348
UniProtKB:A0A8M9QEB4	InterPro	1345

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wdr19-201 (1) Ensembl	Ensembl	4,352 nt	Select Tool ZFIN BLAST
mRNA	wdr19-202 (1) Ensembl	Ensembl	724 nt	Select Tool ZFIN BLAST
mRNA	wdr19-204 (1) Ensembl	Ensembl	4,119 nt	Select Tool ZFIN BLAST
mRNA	wdr19-205 (1) Ensembl	Ensembl	390 nt	Select Tool ZFIN BLAST
mRNA	wdr19-206 (1) Ensembl	Ensembl	324 nt	Select Tool ZFIN BLAST
mRNA	wdr19-207 (1) Ensembl	Ensembl	2,574 nt	Select Tool ZFIN BLAST
ncRNA	wdr19-003 (1) Ensembl	Ensembl	501 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations