Gene
ern2
- ID
- ZDB-GENE-090312-15
- Name
- endoplasmic reticulum to nucleus signaling 2
- Symbol
- ern2 Nomenclature History
- Previous Names
-
- si:ch211-14k19.11
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to have endoribonuclease activity; protein serine/threonine kinase activity; and unfolded protein binding activity. Predicted to be involved in IRE1-mediated unfolded protein response and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress. Predicted to localize to IRE1-TRAF2-ASK1 complex. Is expressed in liver. Orthologous to human ERN2 (endoplasmic reticulum to nucleus signaling 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR010513 | KEN domain |
| Family | IPR045133 | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011047 | Quinoprotein alcohol dehydrogenase-like superfamily |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR038357 | KEN domain superfamily |
| Repeat | IPR018391 | Pyrrolo-quinoline quinone beta-propeller repeat |
Domain Details Per Protein
| Protein | Length | KEN domain | KEN domain superfamily | Protein kinase domain | Protein kinase-like domain superfamily | Pyrrolo-quinoline quinone beta-propeller repeat | Quinoprotein alcohol dehydrogenase-like superfamily | Serine/threonine-protein kinase, active site | Serine/threonine-protein kinase/endoribonuclease IRE1/2-like | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3B496
|
776 | |||||||||
|
UniProtKB:A0A8M9Q0A4
|
777 | |||||||||
|
UniProtKB:A0A8M1QQI8
|
930 | |||||||||
|
UniProtKB:A0A8M9PPK0
|
931 |
Interactions and Pathways
No data available
Plasmids
No data available