Gene
myo15ab
- ID
- ZDB-GENE-090312-149
- Name
- myosin XVAb
- Symbol
- myo15ab Nomenclature History
- Previous Names
-
- si:ch211-201p7.8 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in actin filament organization and vesicle transport along actin filament. Predicted to act upstream of or within sensory perception of sound. Predicted to be located in cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; actin-based cell projection; and vesicle. Is expressed in neuromast and otic sensory epithelium. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Erickson et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 3 | Alliance | Deafness, autosomal recessive 3 | 600316 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR000299 | FERM domain |
| Domain | IPR000857 | MyTH4 domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR019748 | FERM central domain |
| Domain | IPR041795 | Myosin-XV, FERM domain C-lobe |
| Family | IPR051567 | Unconventional Myosin ATPase |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR035963 | FERM superfamily, second domain |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
| Homologous_superfamily | IPR038185 | MyTH4 domain superfamily |
Domain Details Per Protein
| Protein | Length | FERM central domain | FERM domain | FERM superfamily, second domain | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin-XV, FERM domain C-lobe | MyTH4 domain | MyTH4 domain superfamily | PH-like domain superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Unconventional Myosin ATPase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9Q2K6
|
4355 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
myo15ab-201
(1)
|
Ensembl | 7,128 nt | ||
| mRNA |
myo15ab-202
(1)
|
Ensembl | 438 nt | ||
| mRNA |
myo15ab-203
(1)
|
Ensembl | 498 nt |
Interactions and Pathways
No data available
Plasmids
No data available