Gene
atp11a
- ID
- ZDB-GENE-090311-52
- Name
- ATPase phospholipid transporting 11A
- Symbol
- atp11a Nomenclature History
- Previous Names
-
- si:dkey-251i8.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to act upstream of or within phospholipid transport. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; plasma membrane; and recycling endosome. Is expressed in several structures, including eye; inner ear; neural crest cell; post-vent region; and swim bladder. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human ATP11A (ATPase phospholipid transporting 11A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Hawkey-Noble et al., 2020
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 84 | Alliance | Deafness, autosomal dominant 84 | 619810 |
| hypomyelinating leukodystrophy 24 | Alliance | ?Leukodystrophy, hypomyelinating, 24 | 619851 |
| ?Auditory neuropathy, autosomal dominant 2 | 620384 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR032630 | P-type ATPase, C-terminal |
| Domain | IPR032631 | P-type ATPase, N-terminal |
| Domain | IPR044492 | P-type ATPase, haloacid dehalogenase domain |
| Family | IPR001757 | P-type ATPase |
| Family | IPR006539 | P-type ATPase, subfamily IV |
| Homologous_superfamily | IPR008250 | P-type ATPase, A domain superfamily |
| Homologous_superfamily | IPR023214 | HAD superfamily |
| Homologous_superfamily | IPR023298 | P-type ATPase, transmembrane domain superfamily |
| Homologous_superfamily | IPR023299 | P-type ATPase, cytoplasmic domain N |
| Homologous_superfamily | IPR036412 | HAD-like superfamily |
| PTM | IPR018303 | P-type ATPase, phosphorylation site |
Domain Details Per Protein
| Protein | Length | HAD-like superfamily | HAD superfamily | P-type ATPase | P-type ATPase, A domain superfamily | P-type ATPase, C-terminal | P-type ATPase, cytoplasmic domain N | P-type ATPase, haloacid dehalogenase domain | P-type ATPase, N-terminal | P-type ATPase, phosphorylation site | P-type ATPase, subfamily IV | P-type ATPase, transmembrane domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BIA1
|
1212 | |||||||||||
|
UniProtKB:A0A8M9Q0D9
|
1204 | |||||||||||
|
UniProtKB:F8W2B0
|
1177 | |||||||||||
|
UniProtKB:A0A8M2BIB5
|
1145 | |||||||||||
|
UniProtKB:A0A8M9Q0F1
|
1145 | |||||||||||
|
UniProtKB:A0A8M2BI82
|
1177 | |||||||||||
|
UniProtKB:A0A8M9QFY8
|
1149 | |||||||||||
|
UniProtKB:A0A8N7TDX5
|
1137 | |||||||||||
|
UniProtKB:A0A8M9QFZ2
|
1137 | |||||||||||
|
UniProtKB:A0A8M9Q0D3
|
1212 | |||||||||||
|
UniProtKB:A0A8M2BIQ7
|
1204 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp11a-201
(1)
|
Ensembl | 1,917 nt | ||
| mRNA |
atp11a-203
(1)
|
Ensembl | 3,375 nt | ||
| mRNA |
atp11a-204
(1)
|
Ensembl | 10,460 nt | ||
| mRNA |
atp11a-205
(1)
|
Ensembl | 3,456 nt | ||
| ncRNA |
atp11a-002
(1)
|
Ensembl | 462 nt |
Interactions and Pathways
No data available
Plasmids
No data available