Gene
cnnm2b
- ID
- ZDB-GENE-090311-26
- Name
- cyclin and CBS domain divalent metal cation transport mediator 2b
- Symbol
- cnnm2b Nomenclature History
- Previous Names
-
- cnnm2
- si:ch211-176l1.6 (1)
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable magnesium ion transmembrane transporter activity. Acts upstream of or within brain development and magnesium ion homeostasis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; heart; opercular flap; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| renal hypomagnesemia 6 | Alliance | Hypomagnesemia 6, renal | 613882 |
| Hypomagnesemia, seizures, and impaired intellectual development 1 | 616418 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| schizophrenia | cnnm2ba258/a258 | standard conditions | Thyme et al., 2019 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000644 | CBS domain |
| Domain | IPR002550 | CNNM, transmembrane domain |
| Domain | IPR044751 | Ion transporter-like, CBS domain |
| Family | IPR045095 | Ancient conserved domain protein family |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
| Homologous_superfamily | IPR046342 | CBS domain superfamily |
Domain Details Per Protein
| Protein | Length | Ancient conserved domain protein family | CBS domain | CBS domain superfamily | CNNM, transmembrane domain | Cyclic nucleotide-binding domain superfamily | Ion transporter-like, CBS domain |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AJ29
|
830 | ||||||
|
UniProtKB:F1QIW8
|
807 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnnm2b-201
(1)
|
Ensembl | 4,352 nt | ||
| mRNA |
cnnm2b-202
(1)
|
Ensembl | 2,351 nt |
Interactions and Pathways
No data available
Plasmids
No data available