Gene

trpm4a

ID

ZDB-GENE-090302-3

Name

transient receptor potential cation channel, subfamily M, member 4a

Symbol

trpm4a Nomenclature History

Previous Names

trpm4 (1)
sb:eu515

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Enables calcium-activated cation channel activity. Predicted to be involved in metal ion transport and monoatomic cation transmembrane transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; digestive system; integument; keratinocyte; and posterior pronephric duct. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu515 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With trpm4a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
erythrokeratodermia variabilis et progressiva 6	Alliance	Erythrokeratodermia variabilis et progressiva 6	618531
progressive familial heart block type IB	Alliance	Progressive familial heart block, type IB	604559

Associated With trpm4a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR041491	TRPM, SLOG domain
Family	IPR050927	Transient receptor potential cation channel M

Domain Details Per Protein

Protein	Length	Ion transport domain	Transient receptor potential cation channel M	TRPM, SLOG domain
UniProtKB:S5TRY1 InterPro	1260
UniProtKB:A0A8M2BBK8 InterPro	766
UniProtKB:A0A8M9PCR1 InterPro	1031
UniProtKB:A0A8M2BB87 InterPro	930

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	trpm4a-201 (1) Ensembl	Ensembl		4,659 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations