Gene

nrg2b

ID

ZDB-GENE-090205-2

Name

neuregulin 2b

Symbol

nrg2b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ development and intracellular signal transduction. Predicted to act upstream of or within nervous system development. Predicted to be located in membrane. Predicted to be active in extracellular space. Is expressed in brain; neurons; and spinal cord. Orthologous to human NRG2 (neuregulin 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Honjo et al., 2008

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrg2b Human Ortholog

No data available

Associated With nrg2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR002154	Neuregulin, C-terminal
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin domain subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Family	IPR040180	Neuregulin
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	EGF-like domain	Immunoglobulin domain subtype	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype 2	Neuregulin	Neuregulin, C-terminal
UniProtKB:A0A8M3AZM3 InterPro	701
UniProtKB:E7FGA4 InterPro	705
UniProtKB:A0A8M2B373 InterPro	697
UniProtKB:B9VQL5 InterPro	599
UniProtKB:A0A8M3B5L8 InterPro	705

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
aberrant processed transcript	nrg2b-204 (1) Ensembl	Ensembl	798 nt	Select Tool ZFIN BLAST
mRNA	nrg2b-201 (1) Ensembl	Ensembl	1,873 nt	Select Tool ZFIN BLAST
mRNA	nrg2b-202 (1) Ensembl	Ensembl	4,186 nt	Select Tool ZFIN BLAST
mRNA	nrg2b-203 (1) Ensembl	Ensembl	529 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations