Gene

g6pc1b

ID

ZDB-GENE-081223-2

Name

glucose-6-phosphatase catalytic subunit 1b

Symbol

g6pc1b Nomenclature History

Previous Names

g6pcb

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to enable glucose-6-phosphatase activity. Predicted to be involved in gluconeogenesis and glucose 6-phosphate metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and type 2 diabetes mellitus. Orthologous to human G6PC1 (glucose-6-phosphatase catalytic subunit 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Blanco et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With g6pc1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
glycogen storage disease Ia	Alliance	Glycogen storage disease Ia	232200

Associated With g6pc1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000326	Phosphatidic acid phosphatase type 2/haloperoxidase
Family	IPR016275	Glucose-6-phosphatase
Homologous_superfamily	IPR036938	Phosphatidic acid phosphatase type 2/haloperoxidase superfamily