Gene
frem2a
- ID
- ZDB-GENE-081119-3
- Name
- FRAS1 related extracellular matrix 2a
- Symbol
- frem2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Involved in fin morphogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Is expressed in fin; fin fold pectoral fin bud; median fin fold; pharyngeal arch; and trunk. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Fraser syndrome 2 | Alliance | Fraser syndrome 2 | 617666 |
| isolated cryptophthalmia | Alliance | Cryptophthalmos, unilateral or bilateral, isolated | 123570 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CalX-like domain superfamily | CSPG repeat | FRAS1-related extracellular matrix | FRAS1-related extracellular matrix protein, N-terminal domain | Na-Ca exchanger/integrin-beta4 |
|---|---|---|---|---|---|---|
|
UniProtKB:B6IDE6
|
3113 | |||||
|
UniProtKB:D7PS91
|
3119 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
frem2a-201
(1)
|
Ensembl | 9,873 nt | ||
| mRNA |
frem2a-202
(1)
|
Ensembl | 14,471 nt |
Interactions and Pathways
No data available
Plasmids
No data available