Gene

prop1

ID

ZDB-GENE-081107-40

Name

PROP paired-like homeobox 1

Symbol

prop1 Nomenclature History

Previous Names

si:ch211-93n23.5 (1)

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in adenohypophysis development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Is expressed in hypophysis. Orthologous to human PROP1 (PROP paired-like homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Angotzi et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Angotzi et al., 2011
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prop1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hypopituitarism	Alliance	Pituitary hormone deficiency, combined, 2	262600

Associated With prop1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Family	IPR042412	Homeobox protein prophet of Pit-1
Homologous_superfamily	IPR009057	Homedomain-like superfamily