Gene

grk5l

ID
ZDB-GENE-081105-95
Name
G protein-coupled receptor kinase 5 like
Symbol
grk5l Nomenclature History
Previous Names
  • si:dkey-220o5.1
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and G protein-coupled receptor kinase activity. Involved in determination of left/right symmetry; negative regulation of TOR signaling; and regulation of cilium assembly. Localizes to plasma membrane. Is expressed in several structures, including notochord; otic placode; pronephros; spinal cord; and tail bud. Orthologous to human GRK5 (G protein-coupled receptor kinase 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from Burkhalter et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With grk5l Human Ortholog
No data available
Associated With grk5l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR016137 RGS domain
Family IPR000239 GPCR kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036305 RGS domain superfamily
Homologous_superfamily IPR044926 RGS, subdomain 2
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal GPCR kinase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily RGS domain RGS domain superfamily RGS, subdomain 2 Serine/threonine-protein kinase, active site
UniProtKB:F1R6F6 575
UniProtKB:A0A8M2BEP6 584
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA grk5l-201 (1) Ensembl 2,099 nt
mRNA grk5l-202 (1) Ensembl 1,050 nt
mRNA grk5l-203 (1) Ensembl 900 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations