Gene

pde4d

ID

ZDB-GENE-081105-16

Name

phosphodiesterase 4D, cAMP-specific

Symbol

pde4d Nomenclature History

Previous Names

si:dkey-190g11.2

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in signal transduction. Human ortholog(s) of this gene implicated in acrodysostosis. Is expressed in brain; female organism; and head. Orthologous to human PDE4D (phosphodiesterase 4D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pde4d Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acrodysostosis	Alliance	Acrodysostosis 2, with or without hormone resistance	614613

Associated With pde4d Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR023174	3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain	IPR002073	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain	IPR003607	HD/PDEase domain
Domain	IPR040844	Phosphodiesterase 4 upstream conserved regions (UCR)
Family	IPR023088	3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily	IPR036971	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily

Domain Details Per Protein

Protein	Length	3'5'-cyclic nucleotide phosphodiesterase	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily	3'5'-cyclic nucleotide phosphodiesterase, conserved site	HD/PDEase domain	Phosphodiesterase 4 upstream conserved regions (UCR)
UniProtKB:A0A8M9Q3T2 InterPro	703
UniProtKB:A0A8M3B1W5 InterPro	769
UniProtKB:A0A8M3B4T1 InterPro	726
UniProtKB:A0A8M9PF62 InterPro	92

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	pde4d-201 (1) Ensembl	Ensembl		2,112 nt	Select Tool ZFIN BLAST
mRNA	pde4d-202 (1) Ensembl	Ensembl		1,993 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations