Gene
mcf2lb
- ID
- ZDB-GENE-081104-416
- Name
- mcf.2 cell line derived transforming sequence-like b
- Symbol
- mcf2lb Nomenclature History
- Previous Names
-
- sb:eu830
- si:dkey-46k9.10
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Is expressed in lateral line system; otic placode; and otic vesicle. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu830 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Olson et al., 2024
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR001331 | Guanine-nucleotide dissociation stimulator, CDC24, conserved site |
| Domain | IPR001251 | CRAL-TRIO lipid binding domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR055251 | SOS1/NGEF-like, PH domain |
| Family | IPR051336 | Rho GTPase-activating Guanine Nucleotide Exchange Factors |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR035899 | Dbl homology (DH) domain superfamily |
| Repeat | IPR018159 | Spectrin/alpha-actinin |
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | Dbl homology (DH) domain superfamily | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | Rho GTPase-activating Guanine Nucleotide Exchange Factors | SOS1/NGEF-like, PH domain | Spectrin/alpha-actinin |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8N7T881
|
1093 | ||||||||
|
UniProtKB:A0A8M9Q556
|
1088 | ||||||||
|
UniProtKB:A0A8M9Q336
|
1095 | ||||||||
|
UniProtKB:A0A8M9QBG1
|
1072 | ||||||||
|
UniProtKB:A0A8M9QK90
|
1097 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mcf2lb-201
(1)
|
Ensembl | 5,052 nt | ||
| mRNA |
mcf2lb-202
(1)
|
Ensembl | 1,543 nt | ||
| mRNA |
mcf2lb-203
(1)
|
Ensembl | 1,507 nt | ||
| mRNA |
mcf2lb-204
(1)
|
Ensembl | 5,025 nt | ||
| mRNA |
mcf2lb-205
(1)
|
Ensembl | 5,033 nt |
Interactions and Pathways
No data available
Plasmids
No data available