Gene
plat
- ID
- ZDB-GENE-081104-181
- Name
- plasminogen activator, tissue
- Symbol
- plat Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in plasminogen activation and smooth muscle cell migration. Predicted to act upstream of or within proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in ovarian follicle. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Orthologous to human PLAT (plasminogen activator, tissue type).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR018114 | Serine proteases, trypsin family, histidine active site |
| Active_site | IPR033116 | Serine proteases, trypsin family, serine active site |
| Conserved_site | IPR018056 | Kringle, conserved site |
| Domain | IPR000001 | Kringle |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001254 | Serine proteases, trypsin domain |
| Family | IPR001314 | Peptidase S1A, chymotrypsin family |
| Family | IPR026280 | Tissue plasminogen activator |
| Family | IPR050127 | Serine Proteases (Peptidase S1 Family) |
| Homologous_superfamily | IPR009003 | Peptidase S1, PA clan |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR038178 | Kringle superfamily |
| Homologous_superfamily | IPR043504 | Peptidase S1, PA clan, chymotrypsin-like fold |
Domain Details Per Protein
| Protein | Length | EGF-like domain | Kringle | Kringle, conserved site | Kringle-like fold | Kringle superfamily | Peptidase S1A, chymotrypsin family | Peptidase S1, PA clan | Peptidase S1, PA clan, chymotrypsin-like fold | Serine Proteases (Peptidase S1 Family) | Serine proteases, trypsin domain | Serine proteases, trypsin family, histidine active site | Serine proteases, trypsin family, serine active site | Tissue plasminogen activator |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PR58
|
577 | |||||||||||||
|
UniProtKB:F1QB78
|
578 |
Interactions and Pathways
No data available
Plasmids
No data available