Gene

hipk1a

ID

ZDB-GENE-081031-101

Name

homeodomain interacting protein kinase 1a

Symbol

hipk1a Nomenclature History

Previous Names

si:dkey-229p15.2 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; protein phosphorylation; and smoothened signaling pathway. Predicted to localize to PML body and cytoplasm. Is expressed in female organism. Orthologous to human HIPK1 (homeodomain interacting protein kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Newman et al., 2019

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hipk1a Human Ortholog

No data available

Associated With hipk1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Family	IPR050494	Serine/threonine and dual-specificity kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine and dual-specificity kinase	Serine/threonine-protein kinase, active site
UniProtKB:E7F544 InterPro	1084
UniProtKB:A0A8M3ANW6 InterPro	1124
UniProtKB:A0A8M3AYR0 InterPro	1123
UniProtKB:A0A8M3AN75 InterPro	1085
UniProtKB:A0A8M6Z3Z5 InterPro	1084
UniProtKB:A0A8M9PFM0 InterPro	1125

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hipk1a-201 (1) Ensembl	Ensembl	3,257 nt	Select Tool ZFIN BLAST
mRNA	hipk1a-202 (1) Ensembl	Ensembl	2,100 nt	Select Tool
mRNA	hipk1a-203 (1) Ensembl	Ensembl	267 nt	Select Tool
mRNA	hipk1a-204 (1) Ensembl	Ensembl	3,282 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations