Gene
trpc6b
- ID
- ZDB-GENE-081030-19
- Name
- transient receptor potential cation channel, subfamily C, member 6b
- Symbol
- trpc6b Nomenclature History
- Previous Names
-
- si:dkey-20h16.3
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in metal ion transport; regulation of cytosolic calcium ion concentration; and single fertilization. Predicted to localize to cation channel complex and integral component of plasma membrane. Is expressed in trigeminal motor nucleus. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from von Niederhäusern et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
focal segmental glomerulosclerosis 2 | Alliance | Glomerulosclerosis, focal segmental, 2 | 603965 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Ankyrin repeat | Ankyrin repeat-containing domain superfamily | Ion transport domain | Transient receptor ion channel domain | Transient receptor potential channel, canonical |
---|---|---|---|---|---|---|
UniProtKB:A0A8M1RKV1
|
858 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
trpc6b-201
(1)
|
Ensembl | 2,923 nt | ||
mRNA |
trpc6b-202
(1)
|
Ensembl | 2,118 nt |
Interactions and Pathways
No data available
Plasmids
No data available