Gene

maptb

ID

ZDB-GENE-081027-2

Name

microtubule-associated protein tau b

Symbol

maptb Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization and neuron projection development. Predicted to localize to neuron projection. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Is expressed in nervous system; shield; spinal cord neural tube; and trigeminal placode. Orthologous to human MAPT (microtubule associated protein tau).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With maptb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
frontotemporal dementia	Alliance	Frontotemporal dementia 1, with or without parkinsonism	600274
late onset Parkinson's disease	Alliance	{Parkinson disease, susceptibility to}	168600
Pick's disease	Alliance	Pick disease	172700
progressive supranuclear palsy	Alliance	Supranuclear palsy, progressive	601104
		Supranuclear palsy, progressive atypical	260540

Associated With maptb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR027324	Microtubule associated protein MAP2/MAP4/Tau
Repeat	IPR001084	Microtubule associated protein, tubulin-binding repeat

Domain Details Per Protein

Protein	Length	Microtubule associated protein MAP2/MAP4/Tau	Microtubule associated protein, tubulin-binding repeat
UniProtKB:A0A8M9Q7E7 InterPro	315
UniProtKB:A0A8M3B0V5 InterPro	349
UniProtKB:A0A8M2BJF2 InterPro	317
UniProtKB:A0A8M1RK05 InterPro	309
UniProtKB:A0A8M2BIX4 InterPro	712
UniProtKB:A0A8M9Q3A3 InterPro	720
UniProtKB:A0A8M9PDF7 InterPro	752
UniProtKB:A0A8M9PDH6 InterPro	718
UniProtKB:A0A8M9Q7D2 InterPro	728

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	maptb-201 (1) Ensembl	Ensembl	3,023 nt	Select Tool ZFIN BLAST
mRNA	maptb-202 (1) Ensembl	Ensembl	746 nt	Select Tool
mRNA	maptb-203 (1) Ensembl	Ensembl	1,266 nt	Select Tool
mRNA	maptb-204 (1) Ensembl	Ensembl	719 nt	Select Tool
mRNA	maptb-205 (1) Ensembl	Ensembl	800 nt	Select Tool
mRNA	maptb-206 (1) Ensembl	Ensembl	4,792 nt	Select Tool
mRNA	maptb-207 (1) Ensembl	Ensembl	804 nt	Select Tool
mRNA	maptb-209 (1) Ensembl	Ensembl	3,126 nt	Select Tool ZFIN BLAST
mRNA	maptb-210 (1) Ensembl	Ensembl	3,222 nt	Select Tool ZFIN BLAST
ncRNA	maptb-006 (1) Ensembl	Ensembl	1,383 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations