Gene

pax7b

ID

ZDB-GENE-080917-54

Name

paired box 7b

Symbol

pax7b Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have sequence-specific DNA binding activity. Involved in regulation of xanthophore differentiation and wound healing. Localizes to nucleus. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Is expressed in several structures, including brain; hindbrain neural rod; neural crest cell; pigment cell; and trunk. Orthologous to human PAX7 (paired box 7).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Nord et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pax7b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
alveolar rhabdomyosarcoma	Alliance	Rhabdomyosarcoma 2, alveolar	268220
congenital myopathy 19	Alliance	Congenital myopathy 19	618578

Associated With pax7b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR001523	Paired domain
Domain	IPR003654	OAR domain
Domain	IPR022106	Paired box protein 7, C-terminal
Domain	IPR043182	Paired DNA-binding domain
Family	IPR043565	PAX family
Homologous_superfamily	IPR009057	Homedomain-like superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily