Gene

wnk1a

ID

ZDB-GENE-080917-49

Name

WNK lysine deficient protein kinase 1a

Symbol

wnk1a Nomenclature History

Previous Names

im:7165255

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Involved in angiogenesis. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Is expressed in central nervous system; head; neural tube; notochord; and trunk. Orthologous to human WNK1 (WNK lysine deficient protein kinase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7165255 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Lai et al., 2014
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wnk1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary sensory and autonomic neuropathy type 2A	Alliance	Neuropathy, hereditary sensory and autonomic, type II	201300
		Pseudohypoaldosteronism, type IIC	614492

Associated With wnk1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Family	IPR050588	With No Lysine (K) Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase OSR1/WNK, CCT domain	With No Lysine (K) Ser/Thr Protein Kinase
UniProtKB:X1WG08 InterPro	1606
UniProtKB:E7F2F9 InterPro	1634
UniProtKB:A0A8M3APR3 InterPro	1633
UniProtKB:A0A8M9PHD0 InterPro	1264
UniProtKB:A0A8M9QA82 InterPro	1263
UniProtKB:A0A8M1RI56 InterPro	1605

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	wnk1a-201 (1) Ensembl	Ensembl	5,357 nt	Select Tool ZFIN BLAST
mRNA	wnk1a-202 (1) Ensembl	Ensembl	8,103 nt	Select Tool
mRNA	wnk1a-203 (1) Ensembl	Ensembl	5,273 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations