Gene

nos2b

ID
ZDB-GENE-080916-1
Name
nitric oxide synthase 2b, inducible
Symbol
nos2b Nomenclature History
Previous Names
  • inosb
  • inducible nitric oxide synthase b
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; and nucleotide binding activity. Involved in inflammatory response to wounding and response to lipopolysaccharide. Predicted to localize to several cellular components, including cytosol; nucleus; and vesicle membrane. Is expressed in several structures, including diencephalon; digestive system; head; pleuroperitoneal region; and reproductive system. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nos2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Malaria, resistance to} 611162
Associated With nos2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001094 Flavodoxin-like
Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
Domain IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
Domain IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain IPR004030 Nitric oxide synthase, N-terminal
Domain IPR008254 Flavodoxin/nitric oxide synthase
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Family IPR012144 Nitric-oxide synthase, eukaryote
Family IPR050607 Nitric Oxide Synthase (NOS)
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous_superfamily IPR029039 Flavoprotein-like superfamily
Homologous_superfamily IPR036119 Nitric oxide synthase, N-terminal domain superfamily
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Homologous_superfamily IPR044940 Nitric oxide synthase, domain 2 superfamily
Homologous_superfamily IPR044943 Nitric oxide synthase, domain 1 superfamily
Homologous_superfamily IPR044944 Nitric oxide synthase, domain 3 superfamily
Domain Details Per Protein
Protein Length FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Flavodoxin-like Flavodoxin/nitric oxide synthase Flavoprotein-like superfamily Flavoprotein pyridine nucleotide cytochrome reductase NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily Nitric oxide synthase, domain 1 superfamily Nitric oxide synthase, domain 2 superfamily Nitric oxide synthase, domain 3 superfamily Nitric-oxide synthase, eukaryote Nitric Oxide Synthase (NOS) Nitric oxide synthase, N-terminal Nitric oxide synthase, N-terminal domain superfamily Oxidoreductase FAD/NAD(P)-binding Riboflavin synthase-like beta-barrel Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
UniProtKB:A0A8M2B421 687
UniProtKB:A9JNR5 1077
UniProtKB:A0A8M3AHD3 939
UniProtKB:F1QML0 1077
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA nos2b-201 (1) Ensembl 3,428 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations