Gene

slc7a5

ID

ZDB-GENE-080818-4

Name

solute carrier family 7 member 5

Symbol

slc7a5 Nomenclature History

Previous Names

LAT1 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable L-amino acid transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and neutral amino acid transport. Predicted to act upstream of or within amino acid transport and transmembrane transport. Predicted to be located in membrane. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in cholangiocarcinoma; colon cancer; hepatocellular carcinoma; and lung squamous cell carcinoma. Orthologous to human SLC7A5 (solute carrier family 7 member 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 4 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Colón-Rodríguez et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc7a5 Human Ortholog

No data available

Associated With slc7a5 Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	slc7a5^tup1b/tup1b (NHGRI-1)	standard conditions	Colón-Rodríguez et al., 2020
autism spectrum disorder	slc7a5^tup1b/+ (NHGRI-1)	standard conditions	Colón-Rodríguez et al., 2020