Gene

keap1b

ID

ZDB-GENE-080508-1

Name

kelch-like ECH-associated protein 1b

Symbol

keap1b Nomenclature History

Previous Names

klhl19 (1)
zgc:171654

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Acts upstream of or within cellular response to prostaglandin stimulus and cellular response to xenobiotic stimulus. Predicted to be located in cytoplasm and inclusion body. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including gill; head; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Nguyen et al., 2020
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With keap1b Human Ortholog

No data available

Associated With keap1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR011705	BTB/Kelch-associated
Domain	IPR030563	Kelch-like ECH-associated protein 1, BTB/POZ domain
Domain	IPR047098	Kelch-like ECH-associated protein 1, BACK domain
Family	IPR017096	BTB-kelch protein
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR015915	Kelch-type beta propeller
Repeat	IPR006652	Kelch repeat type 1

Domain Details Per Protein

Protein	Length	BTB/Kelch-associated	BTB-kelch protein	BTB/POZ domain	Kelch-like ECH-associated protein 1, BACK domain	Kelch-like ECH-associated protein 1, BTB/POZ domain	Kelch repeat type 1	Kelch-type beta propeller	SKP1/BTB/POZ domain superfamily
UniProtKB:A0A2R8Q1W5 InterPro	587
UniProtKB:A0A8M9Q5W8 InterPro	593

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	keap1b-201 (1) Ensembl	Ensembl	3,053 nt	Select Tool ZFIN BLAST
mRNA	keap1b-202 (1) Ensembl	Ensembl	3,059 nt	Select Tool ZFIN BLAST
mRNA	keap1b-203 (1) Ensembl	Ensembl	2,911 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations